Camilla Luddington Shares Health Update After Hashimoto’s Diagnosis (Exclusive)

Camilla Luddington is adapting to life with a new health condition. 

In an exclusive interview with PEOPLE at the 2025 Inspiration Awards benefiting Step Up in Los Angeles, the Grey’s Anatomy actress revealed how her life has changed since she was diagnosed with Hashimoto’s disease earlier this year. 

“It’s still new to me,” Luddington, 42, explained of the autoimmune disorder. “I got the diagnosis at the beginning of summer, so I’m fresh into this journey. I am on Levothyroxine, which is a thyroid medicine, and I can tell you that a lot of things have changed.”

“I feel like I have so much less inflammation,” she continued. “I was very puffy all the time, not knowing why I was exhausted. I was not working out. I hadn’t seen a workout class in years, and I’m back at Barry’s bootcamp lifting weights. So I feel more myself. I feel like I have more energy for work, for my family.”

Added the star: “It feels like a lot of self-care at this point, just avoiding gluten and all these things that I’m sort of learning.”

Along with feeling more like herself, Luddington reflected on how much clarity the diagnosis brought her after months of navigating symptoms with no explanation. 

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“One thing that I couldn’t understand was I had a lot of brain fog, and now I understand that when your thyroid is sort of all over the place, that’s what that can feel like,” Luddington recalled. “The exhaustion of brain fog. So just literally being able to be present with whoever on set, with my family, is a huge difference.”

The actress, who shares daughter Hayden Alan, 8, and son Lucas Matthew Alan, 5, with husband Matthew Alan, initially shared her diagnosis on her and Grey’s Anatomy costar Jessica Capshaw’s Call It What It Is podcast. 

“Long as you’ve been listening to us, you’ve known that I joke about being slothy,” she said during their Aug. 6 episode. “Just a little slower. Slower, tired, wanna be in bed, love a nap. It never occurred to me that there could be a medical reason for that.”

Ultimately, routine blood work that Luddington had been putting off helped her find her diagnosis with Hashimoto’s disease, which affects the thyroid gland, per the Mayo Clinic.

“I remember hearing the words ‘autoimmune disease’ and thinking, ‘What the f—?’ ” Luddington said. “You know what? I knew something was up. Because even when I was having my blood drawn, the doctor said to me, ‘Is there any, you know, particular thing you’re concerned about?’ And I said, ‘Look, I’m really f—— tired all the time.’ ”